New research indicates that people who come off blockbuster slimming jabs like semaglutide or tirzepatide can put back on lost weight far faster than those who end conventional lifestyle programs.
Findings released in a major medical journal points out that while overweight people often shed a large proportion of their body weight while using the jabs, the weight returns at an average rate of nearly a kilo each month upon discontinuation.
"People using these medications should be informed of the danger of rapid rebound weight gain when the medication is stopped," cautioned researcher Dr. Susan Jebb.
That rate of regain means a return to starting weight within about a year and a half.
Comparing Therapies
The study, which examined 37 of studies involving over 9,000 of patients, compared the effects of GLP-1 agonists with conventional dieting.
Scientists emphasize that people who shed pounds through lifestyle changes alone typically have a slower weight regain—perhaps 100 grams monthly—once they finish.
Understanding the Rapid Rebound
Doctors propose the mode of action of the jabs accounts for the amplified regain.
The injections imitate a natural hormone called glucagon-like peptide-1, which controls hunger.
"Sustained high doses of GLP-1 concentrations several times higher than normal could lead to the body to generate a reduced amount of its own natural hormone, and could reduce sensitivity to its effects," noted Dr. Adam Collins, a nutrition expert.
"Discontinuation of this GLP-1 'fix' means appetite is unsuppressed, making excessive eating a significant risk."
A Lifelong Issue?
Medical guidelines suggest the injections for people with weight-linked medical conditions, alongside recommended lifestyle changes.
Professionals say that, due to the high risk of relapse, the therapy is often ongoing.
This view is echoed by drug manufacturers, who say that the findings "underscore the long-term character of excess weight," similar to managing diseases like hypertension.
User Testimonies
Users who have stopped the jabs explain a intense resurgence of hunger.
"I experienced something flipping and you're instantly extremely hungry," said a patient.
This challenge is compounded if users have not adopted permanent lifestyle or habit changes during therapy.
Widespread Use
Recent estimates show that a significant number of adults in the UK have tried weight-loss jabs in the past year, with interest remaining high.
- Adoption is more common among females than men.
- The middle-aged demographic shows the highest usage rates.
- A large proportion obtain the medications through private prescriptions rather than the NHS.
Ultimately, clinicians caution that while the jabs are powerful agents for shedding pounds, they are not a standalone solution and long-term success relies on combined behavioural support.
